Age Effects on Antidepressant-Induced Manic Conversion

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Age effects on antidepressant-induced manic conversion.

BACKGROUND Antidepressant drug therapy can precipitate mania in vulnerable individuals, but little is known about the effects of age on this phenomenon. OBJECTIVE To pharmacoepidemiologically evaluate the risk of conversion to mania by antidepressant class and patient age. DESIGN, SETTING, AND PATIENTS Using an administrative national database of more than 7 million privately insured indivi...

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Antidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness

BACKGROUND Mania seems to be associated with an increased dopamine (DA) transmission. Antidepressant treatments can induce mania in humans and potentiated DA transmission in animals, by sensitizing DA D2 receptors in the mesolimbic system. We have suggested that the sensitization of D2 receptors may be responsible of antidepressant-induced mania. This review aims to report the experimental evid...

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Sociodemographic and Clinical Features of Antidepressant- Induced Hypomanic and Manic Switch in Patients with Bipolar Disorder

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[Manic episodes during antidepressant treatment in bipolar disorder].

OBJECTIVES To review the literature on antidepressant-induced mania, its incidence, clinical presentation, risk factors and treatment. METHODS A Medline search of studies published between 1970 and 2001 was carried out. Open and controlled studies as well as case series with data from more than five patients were included. RESULTS Antidepressant induced mania may differ clinically from spon...

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ژورنال

عنوان ژورنال: Archives of Pediatrics & Adolescent Medicine

سال: 2004

ISSN: 1072-4710

DOI: 10.1001/archpedi.158.8.773